Proteins that inhibit cancer can also help cancer
protein p53 has anti-cancer function, has been the "star protein" in the field of cancer research. But a new study has found that the protein may be a double-edged sword that, in some cases, provides energy for cancer cells and promotes their growth.
P53 protein encoded by p53 gene can inhibit the production of cancer cells, which has been widely concerned as a tumor suppressor protein. But there are questions about studying the p53 protein. For example, while mutations in the p53 gene associated with the protein have been found in more than half of cancer types, they are often absent in patients with liver cancer.
An international team led by researchers at the university of California, San Diego, United States, combined cell samples, mouse models and human patients for a comprehensive study. The results showed that p53 protein could improve tumor metabolism and promote tumor growth.Specifically, p53 ACTS indirectly as a regulator of cancer cell apoptosis, playing a role in the energy center mitochondria of cancer cells, providing alternative energy for cancer cells that should undergo apoptosis through the role of "glycolysis".
The researchers believe that p53 does play a positive role in inhibiting the production of cancer cells, mainly by reducing the "oxidative phosphorylation" of cells, thereby reducing the production of toxins. However, once the tumor has formed, the effect of p53 is "reversed", accelerating the growth and deterioration of the tumor. The researchers believe the new findings provide a cautionary tale for drug development, especially for potential side effects of cancer drugs that try to exploit the anti-cancer mechanism of p53.
Interested in ELISA Kits? If so, welcome to visit our website:
http://www.dldevelop.com
P53 protein encoded by p53 gene can inhibit the production of cancer cells, which has been widely concerned as a tumor suppressor protein. But there are questions about studying the p53 protein. For example, while mutations in the p53 gene associated with the protein have been found in more than half of cancer types, they are often absent in patients with liver cancer.
An international team led by researchers at the university of California, San Diego, United States, combined cell samples, mouse models and human patients for a comprehensive study. The results showed that p53 protein could improve tumor metabolism and promote tumor growth.Specifically, p53 ACTS indirectly as a regulator of cancer cell apoptosis, playing a role in the energy center mitochondria of cancer cells, providing alternative energy for cancer cells that should undergo apoptosis through the role of "glycolysis".
The researchers believe that p53 does play a positive role in inhibiting the production of cancer cells, mainly by reducing the "oxidative phosphorylation" of cells, thereby reducing the production of toxins. However, once the tumor has formed, the effect of p53 is "reversed", accelerating the growth and deterioration of the tumor. The researchers believe the new findings provide a cautionary tale for drug development, especially for potential side effects of cancer drugs that try to exploit the anti-cancer mechanism of p53.
Interested in ELISA Kits? If so, welcome to visit our website:
http://www.dldevelop.com
